Nitroglycerine – a blessing for mankind
Ursula Quitterer, Professor of Molecular Pharmacology, regards the discovery of antibiotics as one of chemistry’s great achievements. She says chemistry needs more creative lateral thinkers to develop new medicines.
What do you consider to be chemistry’s biggest
achievement or most important discovery?
As a
pharmacologist, I assess chemistry’s discoveries in relation to their importance
for the development of essential life-saving medicines. In this respect, the
discovery of antibiotics, especially penicillin, was one of the biggest
achievements of the last century. The epoch-making significance of
penicillin-like antibiotics is reflected in the sudden lengthening of life
expectancy that was made possible by this class of chemical agents.
What do you deal with in your research, and how
will it affect or benefit our everyday lives?
My work group’s research in molecular
pharmacology is focused on studying active ingredients and action mechanisms to
treat cardiovascular diseases – the most frequent cause of death in
industrialised countries. Medicines which inhibit the angiotensin system and
which are used to treat cardiovascular diseases are now among the most
frequently employed therapeutic agents. Our research contributes to a better
understanding of the mode of operation of this system, which is currently the
most important target for medicines, to enable drugs to be deployed even more
effectively in the fight against high blood pressure, heart attack and heart
failure.
What fascinated you
about chemistry?
For a
pharmacologist, chemistry is an apparently boundless opportunity to design and
synthesise potential new active ingredients and medicines. The fact that
chemistry was often “ahead of its time” is especially fascinating. The majority
of the medicines and groups of active ingredients that have been successfully deployed
to date were isolated or synthesised and developed in collaboration with
pharmacologists long before fundamental biological research was able to explain
the associated targets and target structures.
Which areas of research in chemistry will be
particularly important in the future, and why?
Again, as a pharmacologist, my answer is
subjective. In spite of all medical advances, the medicines currently used to treat
the most common fatal illnesses – cardiovascular diseases, cancers, respiratory
tract diseases or neurodegenerative diseases – are inadequate. Here there is an
urgent need for new active ingredients and reference substances, which can only
be solved by creative lateral thinkers in the chemical sciences.
Which chemical concept should everyone be aware
of by the end of the International Year of Chemistry, and why?
Nitroglycerine
– it is the main constituent of dynamite developed by Alfred Nobel and, for
over 100 years, it has been a life-saving medicine for the treatment of angina.
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